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患有初级单症状夜间尿尿的儿童的大脑微观结构:一个扩散性皮质图像学研究

Xindi Lin¹, Yusong Sun², Dongdong Chen²

¹Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

European journal of pediatrics

|November 10, 2025

概括

儿童的初级夜间尿尿症 (PMNE) 与多个神经网络中的大脑微观结构变化有关. 这些差异,特别是在小脑和默认模式网络中,与排尿欲望唤醒 (MDA) 功能障碍相关.

科学领域:

神经成像是一种神经成像.
儿科神经学儿科神经学
大脑微观结构的大脑微观结构

背景情况:

主要单症状夜间尿尿症 (PMNE) 经常与排尿欲望唤醒 (MDA) 功能障碍有关.
以前的MRI研究表明,PMNE儿童的大脑区域变化,影响了注意力,感官运动,突出性和默认模式网络.

研究的目的:

通过扩散皮质成像 (DKI) 来研究PMNE儿童的大脑微结构差异.
探索这些微观结构变异与MDA功能障碍严重程度之间的关系.

主要方法:

DKI对26名患有PMNE的儿童和26名健康对照进行了应用.
统计分析包括AlphaSim校正的t测试和与Bonferroni校正的Spearman相关性.

主要成果:

患有PMNE的儿童在多个大脑网络中表现出微观结构差异,包括执行控制,注意力,感觉运动,突出性,默认模式,视觉网络和小脑.
MDA 功能障碍的严重程度与 DKI 度量相关,特别是小脑中的辐射曲解以及默认模式和视觉网络区域中的平均/轴性曲解.

结论:

PMNE与神经网络的发育变异有关,影响大脑的微观结构.
微观结构差异与MDA功能障碍有关,为PMNE的神经发育基础提供了洞察力.

关键词:

扩散曲解成像 - 扩散曲解成像功能性磁共振成像技术功能性磁共振成像技术微调的欲望唤醒功能功能唤醒欲望病变的发生和发病.主要单症状的夜间尿尿失禁.

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