通过KEAP1-NRF2-ARE轴通过10-gingerol进行软骨细胞外基质再生,用于骨关节炎治疗
Yibo Ma1, Chenhao Sun2, Zongyue Wang3
1Department of Orthopedics, The Second Hospital of Dalian Medical University, Dalian, China.
Archives of pharmacal research
|November 10, 2025
概括
生醇,特别是10-G,通过减少氧化应激,炎症和亡,在骨关节炎 (OA) 治疗中表现有前途. 这种化合物通过KEAP1-NRF2-ARE通路促进软骨再生.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨关节炎 (OA) 涉及氧化应激,炎症和亡,破坏了软骨细胞外矩阵 (ECM) 稳定.
- 生醇具有生物活性,表明对OA的治疗潜力.
研究的目的:
- 研究OA治疗中的生醇的可行性,有效性和机制.
- 为了确定OA治疗中最有效的生醇化合物.
主要方法:
- 在OA模型中评估了生醇的抗氧化,抗炎和抗瘤活性.
- 评估了10-G对ECM相关基因表达的影响.
- 研究了涉及NRF2,KEAP1和炎症/亡途径的分子机制.
主要成果:
- 10-G显示出强大的抗氧化,抗炎和抗的作用.
- 10-G调节的ECM基因表达,有利于合成而不是降解.
- 10-G激活了KEAP1-NRF2-ARE通路,抑制了关键的炎症激酶和亡调节剂.
结论:
- 10-G通过准KEAP1-NRF2-ARE轴来缓解OA的特征,减少氧化应激,炎症和亡.
- 10-G通过恢复ECM平衡来促进软骨再生,将其定位为潜在的OA治疗方法.
相关概念视频
02:26NF-κB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include: