剖析正常和异常的人类脏发育使用多omics
Luna S Klomp1, Lampros Mavrommatis2, Fanny O Arcolino1,3
1Department of Pediatric Nephrology, Emma Children's Hospital - Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Journal of the American Society of Nephrology : JASN
|November 10, 2025
概括
多omics方法为先天异常提供了新的见解,改善了诊断和治疗. 整合分子数据改变了对发育和疾病的理解,以获得更好的患者结果.
科学领域:
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
- 基因组学就是基因组学.
- 蛋白质组学是指蛋白质组学
- 代谢学 代谢学 代谢学
背景情况:
- 先天性异常往往导致慢性病 (CKD),预后不佳.
- 了解基因基础和变异对发育的生物学影响是有限的.
- 目前对先天异常的诊断和治疗干预措施是不够的.
研究的目的:
- 审查多学科的方法,以了解先天性异性.
- 探索转录组学,表观组学,蛋白组学和代谢组学在发育和疾病中的应用.
- 讨论多态学在精确诊断和治疗方面的潜力.
主要方法:
- 审查单细胞和空间多组技术.
- 分子数据的分析包括转录组学,表观组学,蛋白组学和代谢组学.
- 讨论发育空间绘图的技术能力和挑战.
主要成果:
- 多种奥米学能够更深入地了解先天异常的生物学意义.
- 分子洞察力的整合可以澄清遗传和非遗传疾病机制.
- 案例研究表明,在实验设计中,多种omics的实用性.
结论:
- 多种omics方法对先天异常的精确诊断和预后有希望.
- 整合分子数据可以促进对病机制的理解.
- 多种omics有可能彻底改变先天异常的治疗方法,改善患者的护理.
更多相关视频
10:31Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
593
07:35Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
Published on: February 17, 2023
2.3K
相关概念视频
Internal Anatomy of the Kidney
5.9K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
5.9K
External Anatomy of the Kidney
3.3K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
3.3K
Kidney Structure
74.7K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
74.7K
Imaging Studies I: Kidney, Ureter, and Bladder Studies
252
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
252
Renal Corpuscle
6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
