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Updated: Jan 11, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

536

绘制疾病中的功能障碍蛋白与蛋白相互作用的地图.

Anna Rodina1, Hediye Erdjument-Bromage2, Mara Monetti3

  • 1Chemical Biology Program, Memorial Sloan Kettering Cancer Center.

Journal of visualized experiments : JoVE
|November 10, 2025
PubMed
概括

我们开发了一种名为功能障碍蛋白蛋白相互作用体 (dysfunctional Protein-Protein Interactome,dfPPI) 的新化学蛋白质组方法,用于绘制疾病中的蛋白相互作用网络变化. 这种方法揭示了传统方法错过的关键蛋白质网络功能障碍.

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