患有心力衰竭,肉类和查加斯病的人:系统性审查和元分析
Melissa Orlandin Premaor1, Suellen de Azevedo Mendes1, Gustavo Henrique Silva Ambrósio Vieira1
1Department of Clinical Medicine, Medical School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
PLoS neglected tropical diseases
|November 10, 2025
概括
心力衰竭患者有较高的萨尔科佩尼亚风险,患病率根据定义有所不同. 与查加斯病相关的心力衰竭可能比其他原因更为危险.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 公共卫生 公共卫生
背景情况:
- 心力衰竭 (HF) 是一种复杂的疾病,与显著的发病率有关.
- 随着年龄的增长,骨肌肉质量和功能的丧失,即萨尔科佩尼亚,越来越多地被认为是慢性疾病的并发症.
- 在心力衰竭人群中 Sarcopenia 的患病率和特定风险因素需要进一步阐明.
研究的目的:
- 系统地审查和估计被诊断患有心力衰竭 (HF) 的人群中肉类的患病率.
- 为了比较由查加斯病引起的心力衰竭 (HF-C) 和由其他原因引起的心力衰竭 (HF-NC) 之间的sarcopenia的患病率.
主要方法:
- 进行了全面的系统审查,包括随机对照试验,队列研究,横截面研究和病例控制研究.
- 包括涉及18岁以上心力衰竭患者的研究,其中评估了肉症的频率.
- 进行了数据提取和综合,以估计肉症的患病率,并对HF亚组进行比较.
主要成果:
- 系统性审查从3347个记录的初始搜索中确定了25项相关研究.
- 在心力衰竭患者中,使用EWGSOP2标准估计,类病的总流行率为23.27%.
- 患病率根据使用的诊断标准 (p=0.0002) 有显著的差异,在HF中萨尔科佩尼亚的整体几率比为2.3.
- 两项专注于HF-C的研究报告了麻症的患病率为24.2%,与HF-NC相比的几率比率为1.93,尽管这没有达到统计学意义.
结论:
- 患有心力衰竭的患者表现出患上缩症的风险较高.
- 报告的肉类的患病率受到研究中采用的特定诊断标准的影响.
- 有证据表明,与HF-NC相比,HF-C患者的萨尔科佩尼亚风险可能更高,需要进一步调查.
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