在正常发育和再生过程中,辅酶运输将干细胞放置在血管变体中
Xixi Zhang1, Xiaoyu Wang2, Ondřej Smetana1
1Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences and Viikki Plant Science Centre, University of Helsinki, Helsinki 00014, Finland.
概括
辅酶的积累指导了Arabidopsis根的干细胞组织. 不分化的体细胞充当储存体,在受伤后再生干细胞,对于变形体的发育和修复至关重要.
科学领域:
- 植物生物学 植物生物学
- 发育生物学是发展生物学.
- 干细胞研究的研究.
背景情况:
- 血管变体干细胞产生二次的花和树.
- 在阿拉比多普西斯的根,干细胞靠近主要的树枝,这表明它的组织作用.
研究的目的:
- 调查奥素运输和初级体细胞在血管变体干细胞组织中的作用.
- 了解干细胞再生和的形成,以应对损伤.
主要方法:
- 切除主要体标识 (PXI) 细胞.
- 暂时干扰auxin运输的作用.
- 切除二次体标识 (SXI) 细胞.
- 对干细胞再生和复杂化的观察.
主要成果:
- 在PXI细胞中的auxin积累定义了在初级发育期间的血管变异干细胞组织者.
- 脱离PXI细胞或对辅酶运输的干扰导致分散的干细胞的复杂化.
- 切除SXI细胞导致SXI细胞从干细胞再生,反之亦然,形成一个可互换的单元.
- 干细胞再生需要功能性辅酶运输和未分化的体细胞.
结论:
- 不分化的二次体作为干细胞储存库.
- 辅酶运输介导的辅酶积累是干细胞在变体发育和再生中的定位的关键.
- 体同一细胞和干细胞形成一个可互换的单元,一个干细胞利基,对于再生至关重要.
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