坎迪达阿尔比坎斯 (Candida albicans) 和菌 (Enterococcus faecalis) 之间的协同作用促进了毒素依赖宿主细胞损伤
Mario Kapitan1,2,3, Maria Joanna Niemiec1,2, Nicolas Millet4,5
1Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena 07745, Germany.
概括
菌和Enterococcus faecalis共感染会增加宿主细胞的损伤. 这种真菌改变了葡萄糖的可用性,并促进了细菌的粘附性,增强了病原体诱导的损伤和口腔大腺炎的严重程度.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 病变的发生和发病.
背景情况:
- 菌 (Candida albicans) 和菌 (Enterococcus faecalis) 是共享粘膜部位的机会性病原体.
- 这两种微生物都可能导致严重的感染,特别是在失生症期间.
研究的目的:
- 为了研究C. albicans和E. faecalis之间的协同作用.
- 阐明C. albicans加剧E. faecalis介导的宿主细胞损伤的机制.
主要方法:
- 在体外共同培养模型评估宿主细胞损伤.
- 喉类候群病的小鼠模型,以评估疾病的严重程度.
- 细菌粘附和葡萄糖可用性的分析.
主要成果:
- C. albicans的存在显著增加了由E. faecalis引起的宿主细胞损伤.
- 在小鼠模型中,E. faecalis加剧了口腔喉候群病.
- 菌细胞解酶介导的损伤增加,通过物理相互作用和葡萄糖耗尽而增强.
结论:
- 真菌-细菌共感染可以导致增强的病原体.
- 涉及身体接触和营养可用性的相互作用在多微生物感染中至关重要.
- 了解这些复杂的相互作用对于开发有效的治疗策略至关重要.
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