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在 laparoscopic 捐赠者切除术后部外科手术的风险:基于人口的队列研究

Amit X Garg¹, Eric McArthur², Jessica M Sontrop³

¹ICES, Ontario, Canada; Department of Epidemiology & Biostatistics, Western University, London, Ontario, Canada; Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada; London Health Sciences Centre Research Institute, London, Ontario, Canada; and Department of Research Methods, Evidence and Uptake, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada (A.X.G.).

Annals of internal medicine

|November 10, 2025

概括

与非捐赠者相比,活着的男性脏捐赠者在腹腔镜切除术后的阴囊手术风险明显更高. 这项研究突出了长期的并发症,强调需要提高认识和进一步调查原因.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
泌尿器科泌尿器科泌尿器科泌尿器科
移植手术移植手术

背景情况:

活体脏捐献是一种重要的医疗程序.
活着的男性脏捐赠者可能会面临长期并发症,例如囊胀后切除术.
捐赠后囊手术的确切长期风险尚未得到充分确立.

研究的目的:

为了比较活着的男性脏捐赠者与非捐赠者的阴囊手术率.
为了评估经腹腔镜切除术后囊液采集手术的长期风险.
为了调查男性接受者的脏捐赠的潜在并发症.

主要方法:

在加拿大安大略省 (2002-2024) 使用链接的行政医疗保健数据库进行了基于人口的队列研究.
898名经过腹腔镜切除术的活生生的男性脏捐赠者与8980名非捐赠者根据年龄,入院日期,居住地,收入和之前的阴囊/上手术进行了1:10的匹配.
参与者被跟踪平均9年 (长达22年),以确定阴囊手术的发生率.

主要成果:

捐赠者 (7.8%) 与非捐赠者 (0.2%) 相比,囊手术的发生率明显高,风险比率为38.8.8.
从捐赠到阴囊手术的中位时间为5.2年,其中90%以上是水分切除术.
在20年内,阴囊手术的累积发病率在捐赠者中为13.8%,非捐赠者为0.7%.

结论:

在男性活体脏捐赠者中, laparoscopic nephrectomy 与随后的阴囊手术风险显著增加有关.
这些发现表明,脏捐赠的显著长期并发症需要进一步研究因果机制.
对于参与移植的捐赠者和医疗保健提供者来说,意识到这种风险至关重要.

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