类风湿性关节炎的营养状况和脆弱性:多中心观察性研究 (T-FLAG)
Mochihito Suzuki1, Shuji Asai2, Yoshifumi Ohashi3
1Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya Aichi, Japan; Department of Orthopedic Surgery, Japan Community Health care Organization Kani Tono Hospital, Kani, Gifu, Japan.
Archives of gerontology and geriatrics
|November 10, 2025
概括
在类风湿性关节炎 (RA) 患者中,营养状况不佳与虚弱有关,但身体功能可能会调解这种联系. 解决营养,身体功能和社会因素是管理RA脆弱性的关键.
科学领域:
- 类风湿病学 类风湿病学
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 虚弱是老化类风湿性关节炎 (RA) 患者的一个重要问题.
- 导致虚弱的关键因素包括营养不良,身体功能下降和社会隔离.
研究的目的:
- 检查RA患者营养状况和虚弱之间的关联.
- 调查身体功能和社会脆弱性在这种关系中的作用.
主要方法:
- 在三家医院对667名RA患者进行横截面研究.
- 评估营养状况 (GNRI),脆弱 (Kihon检查清单),身体功能 (HAQ-DI) 和社会脆弱 (Makizako指数).
- 利用多变量逻辑回归来识别脆弱的独立预测因素.
主要成果:
- 脆弱性患病率随着营养状况 (GNRI) 较差而增加,从29.6%到66.7% (P < 0.001) 之间.
- GNRI和社会脆弱性最初与脆弱性有关,但在调整身体功能 (HAQ-DI) 后,这种意义消失了.
- 营养状况不佳仍然与较高的虚弱率有关,即使在身体功能良好 (HAQ缓解) 的患者中也是如此.
结论:
- 营养状况与RA患者的脆弱性有关,身体功能可能调解这种关联.
- 对RA患者的综合管理策略应整合营养支持,身体功能改善和社会参与.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
622
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
622
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
470
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
470
Rheumatic Heart Disease I: Introduction
415
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
415
Rheumatic Heart Disease III: Medical Management
272
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
272
Rheumatic Heart Disease IV: Nursing Management
256
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
256
Connective Tissue Cell Types
4.0K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.0K


