走向智能免疫微针:感知,治疗和免疫调节的策略
Zhenyou Ge1, Xingjian Jin2, Bingbing Gao3
1School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, PR China; School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, PR China; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore.
概括
智能微针 (MN) 系统为免疫健康提供了一种新的方法,可实现生物分子的精确传感和治疗性传递. 本综述探讨了它们对先进免疫调节和个性化治疗的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 纳米技术 纳米技术
背景情况:
- 人体免疫系统需要精确的调节才能达到最佳功能.
- 传统的可穿戴设备在检测和传递大型免疫生物分子方面存在局限性.
- 微针 (MN) 技术为访问皮肤免疫元件提供了一个最小侵入性的解决方案.
研究的目的:
- 综合审查智能免疫微针系统的进展.
- 专注于使用MNs的传感,治疗和免疫调节策略.
- 为开发下一代免疫健康解决方案提供框架.
主要方法:
- 免疫MNs的分类,制造和修改.
- 讨论免疫生物标志物的感知策略.
- 治疗应用和智能MN系统的总结.
主要成果:
- MN技术使无痛的透能够直接进入皮肤免疫组件.
- 目前的策略包括生物标志物传感,药物输送以及炎症和癌症的治疗.
- 新兴的智能MN系统集成无线控制,反和机器学习以进行自适应调节.
结论:
- 智能免疫MN系统对适应性和个性化免疫调节具有重大前景.
- 本次审查强调了MN技术在先进免疫健康解决方案中的潜力.
- 进一步的跨学科合作对于开发下一代免疫健康技术至关重要.
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