快速溶解的微针贴片嵌入长效微球,用于持续释放戈塞林
Quanquan Han1, Yunlong Jiao2, Ruisi Cai2
1State Key Laboratory of Advanced Drug Delivery and Release Systems, School of Pharmacy, Zhejiang University, Hangzhou 310058, China; Jinhua Institute of Zhejiang University, Jinhua 321299, China.
概括
一种新型的戈塞林微球载微针 (GSR-MN) 贴片为前列腺癌治疗提供了一种最小侵入性的替代方案. 与传统注射相比,这种贴片可以改善患者的服药性,并减少不适.
科学领域:
- 在瘤学瘤学.
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 戈塞林是通过雄激素剥夺治疗治疗前列腺癌的关键治疗方法.
- 目前的戈塞林输送方法 (植入物,微球) 需要肌肉内注射,导致患者遵守不良和不适.
- 至少侵入性药物输送是必要的,以改善患者的坚持和减少治疗负担.
研究的目的:
- 开发和评估一款戈塞林微球载微针 (GSR-MN) 贴片,作为治疗前列腺癌的患者友好的替代品.
- 评估GSR-MN贴片的安全性,疗效和药物释放概况.
主要方法:
- 制造具有强大的机械强度和快速溶解性能的微针.
- 用戈塞林微球装载微针,用于通过皮肤输送.
- 在体外和体内对药物释放,生物相容性,生物安全性和治疗疗效的评估.
主要成果:
- GSR-MN贴片有效地将戈塞林微球传递到皮肤中.
- 在28天的时间内实现了持续的戈塞林释放.
- 治疗结果与传统的肌肉内注射相当,具有出色的生物相容性和生物安全性.
结论:
- 戈塞林微球装载的微针贴片是前列腺癌中雄激素剥夺治疗的有希望的,最少侵入性的替代方案.
- 这种新型的输送系统有可能显著改善患者的服从性,并减少与治疗相关的不适.
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