在CFD模拟的帮助下,评估了两种双离心机的乳化行为
Nico Hellmund1, Venkatesh Inguva1, Denise Steiner1
1University of Münster, Institute of Pharmaceutical Technology and Biopharmaceutics, Corrensstraße 48, D-48149 Münster, Germany.
International journal of pharmaceutics
|November 10, 2025
概括
双离心法有效地制备了脂质纳米乳液. 这项研究发现,当力密度相似时,使用对称和不对称的双离心机发现了类似的液滴大小,确保了配方的一致性.
科学领域:
- 制药技术 制药技术 制药技术
- 纳米技术纳米技术
- 化学工程是化学工程的重要组成部分.
背景情况:
- 双离心是一种经过验证的方法,用于制造脂质纳米载体,如脂质体和纳米乳液.
- 不同的双离心机设计对配方特性的影响仍然在很大程度上未经调查.
研究的目的:
- 为了比较对称和不对称的双离心机在通过相位逆转乳化制备脂质纳米乳液的有效性.
- 为了建立离心机设计和产生的纳米乳液特性之间的相关性.
主要方法:
- 用对称和不对称的双离心机准备脂质纳米乳液.
- 计算流体动力学 (CFD) 模拟用于量化和比较处理过程中的力密度.
- 进行滴滴大小分析以评估配方特性.
主要成果:
- 在两个离心机类型中,当处理力密度相似时,可以实现可比的液滴大小.
- 工艺变化和从1g扩大到10g并没有显著改变滴滴大小.
- 差价合约模拟为两种离心机设计之间的性能相关性提供了依据.
结论:
- 双离心机的设计 (对称与不对称) 在处理力密度相匹配时不会显著影响脂质纳米乳液滴滴大小.
- 双离心法为可重复的脂质纳米乳液制备提供了强大的和可扩展的技术.
- 强力密度是确保不同双离心机配置一致的结果的关键参数.
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