我们如何预测牛奶过敏的酸奶耐受性?
Hande Yuksel Bulut1, Ezgi Ulusoy Severcan1, Aysegul Ertugrul1
1University of Health Sciences, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey.
Klinische Padiatrie
|November 10, 2025
概括
许多牛奶过敏的孩子可以耐受酸奶. 牛奶的特定IgE水平有效地预测了IgE介导过敏的酸奶在口服食品挑战期间的反应.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 食品科学 食品科学 食品科学
背景情况:
- 牛奶过敏 (CMA) 是儿童常见的食物过敏.
- 关于酸奶对CMA管理的影响的数据有限.
- 酸奶是一种发酵乳制品,可能会改变过敏性.
研究的目的:
- 通过口服食品挑战 (OFC) 评估患有CMA的儿童的酸奶耐受性.
- 确定预测IgE介导CMA中OFC结果的因素.
- 评估特定IgE,皮肤刺伤测试 (SPT) 和IgE/总IgE比率在预测酸奶耐受性的作用.
主要方法:
- 对132名被诊断患有CMA的儿童进行了回顾性分析.
- 分类为IgE介导,非IgE介导和混合类型的反应.
- 对酸奶的人口统计数据,临床病史,实验室结果,SPT和OFC结果的评估.
主要成果:
- 所有参与者的68.2%和IgE介导组的51.5%容忍酸奶.
- 在IgE介导组中,在阳性和阴性OFC结果之间观察到SPT小麦粉大小,特定IgE和IgE/总IgE比率的显著差异 (p<0.05).
- 牛奶特定的IgE在酸奶OFC (AUC0.831-0.876) 期间对任何反应/过敏反应具有很高的预测价值.
结论:
- 许多患有各种形式的CMA的儿童可以耐受酸奶.
- 牛奶的特定IgE水平是IgE介导的CMA中OFC结果的有价值的预测指标.
- 进一步的研究可以完善儿童食物过敏中食物挑战的预测模型.
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