左主通皮或手术重血管化以及随后的过渡性和持续性功能障碍的风险
Laura Novelli1,2, Jorge Sanz-Sanchez3,4, Alessandra Iaccarino5
1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Open heart
|November 10, 2025
概括
急性损伤 (AKI) 在左主冠状动脉疾病 (LMCAD) 重血管化后很常见,在冠状动脉旁路移植 (CABG) 后比穿皮冠状动脉干预 (PCI) 发生的更多. 只有AKI后的持续性功能障碍 (RD) 才能显著影响长期预后.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 干预心脏病学 干预心脏病学
背景情况:
- 急性损伤 (AKI) 是经皮冠状动脉干预 (PCI) 和冠状动脉旁路移植 (CABG) 的已知并发症.
- 关于左主冠状动脉疾病 (LMCAD) 重血管化后的AKI发病率和预后的数据有限,特别是关于持续性功能障碍 (RD) 的数据有限.
研究的目的:
- 为了调查LMCAD再血管化后AKI的发病率和预后影响.
- 为了比较 LMCAD 的 PCI 和 CABG 之间的 AKI 率.
- 评估持续性RD的风险及其与LMCAD重血管化后死亡率的关联.
主要方法:
- 针对LMCAD (2015-2022) 连续接受PCI或CABG的患者的回顾性分析.
- AKI定义为血清肌素增加≥0.3 mg/dL或>50%从基线.
- 持续的RD定义为1年后持续的sCr增加.
- 多变量后勤回归和IPTW用于比较PCI和CABG之间的AKI风险.
- 考克斯回归分析了暂时性和持续性RD的预后影响.
主要成果:
- 其中包括1047名患者 (PCI:617,CABG:430).
- 在PCI后,AKI的发病率为17%,CABG后为28% (调整为OR 2.82).
- AKI增加了一年全因死亡风险.
- 持续的RD,不是短暂的AKI,预后明显恶化 (HR 9.56).
结论:
- 在LMCAD重血管化后,AKI很常见,与PCI相比,CABG后的发病率更高.
- AKI显著影响预后,但主要是在导致持续性功能障碍时.
- 持续性RD的发展是LMCAD重血管化后长期结果的关键因素.
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