确定韩国Helicobacter pylori菌株的流行病学值:对抗生素耐药性模式的基于模型的分析
Jin Hee Noh1, Jung Mogg Kim2, Hwoon-Yong Jung3,4
1Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Gut and liver
|November 10, 2025
概括
确定韩国Helicobacter pylori (H. pylori) 抗生素的流行病学截止值 (ECOFF) 是非常重要的. 这项研究确定了ECOFF和耐药率,有助于H. pylori根除策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 缺乏针对Helicobacter pylori (H. pylori) 的标准化临床最低抑制度 (MIC) 断点.
- 这种缺失导致对H. pylori感染的耐药性定义不一致.
- 建立流行病学值 (ECOFF) 对于标准化H. pylori耐药性评估至关重要.
研究的目的:
- 分析2015年至2023年韩国针对H. pylori的常见抗生素的最小抑制度 (MIC) 分布.
- 确定用于治疗H. pylori的关键抗生素的流行病学值 (ECOFF).
- 为了确定韩国H. pylori分离物中的抗生素耐药性率.
主要方法:
- 对2015年至2023年间从五个数据源中收集的H. pylori分离物的MIC分布的分析.
- 使用序列二倍甲基稀释方法确定MIC值,用于5925个原始H. pylori分离物.
- 利用ECOFFinder计划,为6种常用的抗生素建立ECOFF.
主要成果:
- 确定了临时的ECOFFs:阿莫西西林 (0.125μg/mL),克拉里斯罗米辛 (0.125μg/mL),勒沃素 (0.5μg/mL),美特罗尼达 (8.0μg/mL) 和四环素 (0.25μg/mL).
- 由于数据不足,无法确定里法布丁的ECOFF.
- 由此产生的抗药性率包括:阿莫西西林 (17.9%),克拉利胺素 (31.9%),勒沃素 (40.9%),甲尼达 (24.7%) 和四环素 (11.5%).
结论:
- 在韩国确定了H. pylori的区域抗生素耐药性模式.
- 为指导抗生素敏感性测试,建立了针对韩国特定的ECOFF.
- 为优化H. pylori根除策略和开发临床断点提供了基础.
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