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DAF-16/FOXO和HLH-30/TFEB包括一个合作的监管轴,控制C. elegans中的管状溶酶体诱导

Cristian Ricaurte-Perez¹, Joshua P Gill¹, P Kerr Wall¹

¹Louisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA.

Nature communications

|November 10, 2025

概括

转录因子 DAF-16/FOXO 和 HLH-30/TFEB 合作增强 lysosomal 功能,促进 C. elegans 的健康衰老. 这种相互作用支持后期生活中的全身健康益处.

科学领域:

细胞生物学细胞生物学
衰老研究研究衰老研究
遗传学是一个遗传学.

背景情况:

转录因子DAF-16/FOXO和HLH-30/TFEB与衰老调节有关.
这些因素促进长寿的协同机制仍然不完全理解.

研究的目的:

研究DAF-16/FOXO和HLH-30/TFEB之间的功能相互作用,促进健康的衰老.
阐明 lysosomal tubulation 在这些转录因子调节的寿命路径中的作用.

主要方法:

使用Caenorhabditis elegans作为一个模型生物.
研究了dSVIP过度表达对 lysosomal 形态和转录因子局部化的影响.
分析了全球基因表达变化,包括VPS-34和脂质代谢基因.

主要成果:

DAF-16/FOXO和HLH-30/TFEB合作诱导强大的溶酶体管道,有助于老年C. elegans的健康益处.
溶酶体管管可以通过dSVIP过度表达人工诱导,但需要至少有一个转录因子的存在.
dSVIP过度表达导致DAF-16和HLH-30的核积累,并改变基因表达,促进管状溶酶体活性.

结论:

DAF-16/FOXO和HLH-30/TFEB之间的新功能相互作用通过增强的溶酶体管道支持更健康的衰老.
这个由DAF-16和HLH-30调节的细胞过程,在衰老过程中产生有利于健康的效应.

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