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Updated: Jan 11, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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通过MARCH2介导的Lys63结合的多比基因化促进转移,通过调节TGF-β型I受体的催化活性来促进转移

Kun Tae1, Sang Woo Cho1, Seonjeong Lee2

  • 1Department of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.

Cell death & disease
|November 10, 2025
PubMed
概括

E3泛基因酶MARCH2通过泛基因化增强TGF-β受体ALK5活性,影响细胞迁移和转移. 这一发现揭示了TGF-β信号传递中的新调节机制.

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