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Updated: Jan 11, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
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Published on: December 23, 2010

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在T细胞中,LUBAC调节了TRAF6下游的CBM复杂功能

Carina Graß1, Franziska Ober1, Constanze Sixt1

  • 1Signaling and Immunity, Research Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Munich - German Research Center for Environmental Health, Neuherberg, Germany.

Nature communications
|November 10, 2025
PubMed
概括

线性ubiquitin链组合复合体 (LUBAC) 和TRAF6调节T细胞受体信号传递. 虽然LUBAC对NF-κB激活不至关重要,但它调节MALT1基质识别和BCL10无化,影响T细胞反应.

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