相关实验视频

Updated: Jun 8, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

在易患狼的小鼠中,明显的自反应性CD19^-等离子体细胞子集积累

Van Duc Dang^1,2,3, Franziska Szelinski^1,2, Elodie Mohr¹

¹Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.

Nature communications

|November 10, 2025

概括

研究人员在易患狼的小鼠中确定了一种特定的致病性血细胞 (PC) 子集. 这些CD19阴性PC在全身性红斑狼 (SLE) 患者中得到扩展,这表明了超出CD19的新治疗点.

科学领域:

免疫学免疫学免疫学
这是一种自身免疫力.
分子生物学分子生物学

背景情况:

血细胞 (PCs) 通过自身抗体和细胞因子分泌驱动全身性红斑狼 (SLE) 病原发生.
目前针对所有PC的治疗方法有可能耗尽保护性的长寿命PC.
识别致病性PC子集对于选择性治疗向SLE至关重要.

研究的目的:

在狼中识别和表征疾病和器官特定的病原性血细胞子集.
调查CD19阴性PC在狼病变的起源和潜在作用.
探索这些发现在人类SLE中的翻译相关性.

主要方法:

单细胞RNA测序的一个细胞.
分析B细胞受体谱的分析
狼的遗传小鼠模型
对SLE患者的周围血液进行分析.

主要成果:

在易患狼的小鼠中观察到自反应性CD19阴性PC的显著扩张.
特定的子集,包括类切换的CXCR3+和酸丁胆特定的B-1衍生PC,显示出独特的基因表达特征.
发现CD19阴性PC单向来源于CD19阳性PC.
在SLE患者的外周血液中检测到CD19阴性PC的高频率.

结论:

自主反应性CD19阴性PCs在狼小鼠模型中成为关键的病原特征.
这些细胞参与维持SLE中的致病活性.
对于SLE的治疗策略应该考虑向CD19阴性PC,超越目前的CD19向方法.

更多相关视频

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

相关概念视频

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...