孕期急性运动和高强度间歇训练引起的蛋白质组变化:试点随机对照试验
Dominka Goik1, Anna Szumilewicz2, Natalia Musiał1
1Laboratory of Mass Spectrometry, Intercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk, Poland.
Scientific reports
|November 10, 2025
概括
怀孕期间高强度间歇训练 (HIIT) 通过诱导代谢和免疫适应,显示出对母亲健康的潜在益处. 虽然心肺运动测试会导致立即的变化,但定期的HIIT会导致持续的适应,可能会预防妊娠糖尿病.
科学领域:
- 蛋白质组学和运动生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 身体活动对母亲健康至关重要,世卫组织建议每周进行150分钟的中等强度运动.
- 关于高强度运动,如高强度间歇训练 (HIIT) 在怀孕期间的影响的数据有限.
研究的目的:
- 分析怀孕妇女在心肺运动测试 (CPET) 和8周HIIT计划后尿蛋白质组的变化.
- 通过使用SWATH-MS.了解怀孕期间HIIT影响的分子过程.
主要方法:
- 18名孕妇 (怀孕13-28周) 接受了CPET,以评估心肺呼吸能力.
- 9名女性参加了为期8周的HIIT计划 (每周3次),旨在在厌氧值时超过心率.
- 对照组 (EDU) 的9名女性每周接受健康教育和中度至强度体力活动建议.
主要成果:
- CPET引发了尿路蛋白质组的显著,即时变化,影响了参与结合,酶抑制和免疫通路 (例如,中性粒细胞脱粒化) 的蛋白质.
- 8周的HIIT与CPET相比,随着时间的推移显示出较少的蛋白质组变化,表明了适应.
- 与胰岛素抵抗相关的TFF2等蛋白质的下调,表明HIIT在预防妊娠糖尿病方面具有潜在的益处.
结论:
- CPET引发了急性代谢和免疫反应,而定期的HIIT促进了孕妇的有益适应.
- 通过影响与胰岛素抵抗相关的途径,HIIT可能会对妊娠期糖尿病产生保护作用.
- 这项试点研究为HIIT在怀孕期间的影响提供了新的蛋白质学视角,突出了其改善孕产妇健康的潜力.
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