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Updated: Jan 11, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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拼接因子PTBP1与RUNX1相互作用,对于白血病细胞存活是必需的

Arjun Dhir1,2, Alexander Ethell1,2,3, Riley Watkins1,2

  • 1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

Leukemia
|November 10, 2025
PubMed
概括

与Runt相关的转录因子1 (RUNX1) 与聚胺管结合蛋白1 (PTBP1) 相互作用,调节基因表达和RNA剪接. 这种相互作用通过控制代谢基因表达,对白血病细胞生存至关重要.

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