剖腹产修改了产前外源性孕激素和密码症之间的关联:一个病例对照研究
Junfeng Zhao1, Xiaoqiang Cheng2, Zhan Shi2
1Department of Pediatric Urology, Ningbo University Affiliated Women and Children's Hospital, Ningbo, China. fezhaojunfeng@nbu.edu.cn.
European journal of pediatrics
|November 10, 2025
概括
产前暴露于外源性孕激素会增加密码体症的风险,特别是在通过剖腹产分娩的婴儿中. 这种关联突出了对男性生殖发育的潜在环境影响.
科学领域:
- 生殖医学 生殖医学
- 儿科手术 儿科手术
- 内分泌学 在内分泌学.
背景情况:
- 密码症 (未下降的丸) 是一种常见的先天性疾病,具有多因素的病因.
- 周围产生的因素,如早产,低出生体重和内分泌干扰,都与其发展有关.
- 产前外源性孕激素暴露的作用及其与分娩方式的相互作用仍然不完全理解.
研究的目的:
- 为了调查产前外源性孕激素暴露与密码体的风险之间的关联.
- 要确定传递方式是否会改变这种关联.
主要方法:
- 追溯病例控制研究,涉及610例密症病例和610例对照.
- 从儿科外科住院 (2016年4月-2021年10月) 提取的数据.
- 多变量逻辑回归用于分析关联和相互作用,控制共变量.
主要成果:
- 产前外源性孕激素暴露显著与加大密码症的几率相关 (aOR=1.85).
- 交付模式显著改变了这种关联 (相互作用P=.001).
- 与阴道分娩 (aOR=1.28) 相比,剖腹产 (aOR=3.27) 的相关性更强.
- 在剖腹产子组中,暴露于孕激素的婴儿显示出更高的早产率和低出生体重.
结论:
- 产前外源性孕激素暴露与较高的密码性发育风险有关,特别是在剖腹产产后的婴儿中.
- 在剖腹产中较强的关联可能受到病例组合差异的影响,包括更高的早产率和低出生体重.
- 需要进一步的前性研究来证实这些发现并阐明潜在的机制.
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