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在前列腺癌中测序和结合基于PSMA的治疗方法的新兴证据

Sola Adeleke¹, Joao R Galante², Yishen Wang³

¹School of Biomedical Engineering and Imaging Sciences (BMEIS), King's College London, London, UK. olusola.adeleke@kcl.ac.uk.

Nature reviews. Urology

|November 10, 2025

概括

前列腺特异性膜抗原 (PSMA) 是晚期前列腺癌的关键目标. 针对PSMA的治疗方法,包括放射性体和新型药物合物,有望改善治疗结果.

科学领域:

在瘤学瘤学.
放射化学放射化学是指辐射化学.
免疫治疗是一种免疫疗法.

背景情况:

前列腺特异性膜抗原 (PSMA) 在前列腺癌细胞中高度表达,特别是在晚期阶段.
增加PSMA表达和活性与增加的瘤增殖,转移和割抵抗相关.

研究的目的:

审查前列腺癌PSMA向治疗的进展.
探索将基于PSMA的策略与现有治疗方法相结合的潜力.

主要方法:

对PSMA向性联体的放射生物化学进展的审查.
对FDA批准的放射追踪剂和放射治疗药物的分析.
检查基于PSMA的新组合方法.

主要成果:

多个针对PSMA的放射性标记联体被FDA批准用于临床使用.
新兴的基于PSMA的疗法包括抗体-药物联合体和放射性核酸有效载荷.
作为免疫疗法和CAR T细胞疗法的特定目标,PSMA.

结论:

针对PSMA的疗法为晚期前列腺癌治疗提供了一个有前途的途径.
将PSMA策略与标准治疗相结合的组合方法可能会改善患者的治疗结果.
作为一种特定抗原,PSMA的作用有助于在免疫疗法中精确识别瘤.

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