益生菌可以恢复GABAergic神经元并减轻周周结核白血病中产后发作
Jia-Shing Chen1, Ming-Jung Tu2, Yu-Ming Chang3,4
1School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.
Nutritional neuroscience
|November 11, 2025
概括
益生菌可以预防在周周结核白血病 (PVL) 脑损伤后. 补充剂减少了发作,神经炎症,并通过影响肠-大脑轴来恢复GABAergic神经元.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 在早产婴儿中,产后经常跟随周周结膜性白血病 (PVL),往往证明耐治疗.
- 在PVL引起的和有效的预防策略背后的机制仍然在很大程度上是未知的.
- 益生菌,以调节肠道微生物群和减少炎症而闻名,呈现出潜在的治疗途径.
研究的目的:
- 在大鼠模型中研究益生菌补充剂在预防或减轻发作和随之而来的神经病理后PVL的疗效.
- 在PVL的背景下探索益生菌对神经炎症的影响,GABAergic神经元完整性和肠道微生物群组成.
主要方法:
- 周心室白血病 (PVL) 通过缺氧缺血和脂多糖在老鼠中被诱导.
- 评估了发作易感性,神经炎症标志物 (微结质,TNF-α),GABA活性神经元密度和肠道微生物群.
- 在受伤前和之后,老鼠在益生菌中 (GOS,FOS) 接受了一种多菌株益生菌配方 (Lactobacillus,Bifidobacterium).
主要成果:
- 在PVL小鼠中,发作的频率和持续时间增加,微质,寡细胞减少,骨髓蛋白减少.
- 在PVL大鼠中,皮质GABAergic神经元的显著减少,特别是体静止素阳性内部神经元.
- 益生菌治疗恢复了GABAergic神经元,减少了发作活动,减少了微质激活,降低了TNF-α水平.
- 益生菌调节了肠道微生物群的组成,增加了便和脑脊液 (CSF) 中的黄油酸水平.
结论:
- 益生菌补充剂在减少PVL脑损伤后的活动方面显示出有前途.
- 治疗效果似乎通过肠-大脑轴介导,涉及减少神经炎症和恢复GABAergic神经元.
- 益生菌可能代表一种可行的辅助疗法,用于预防患有PVL的婴儿.
相关概念视频
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
1.2K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.2K
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
802
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
802
01:14Antiepileptic Drugs: Glutamate Antagonists
876
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
876
01:24Epilepsy and Seizures: Overview
1.1K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K