慢性鼻炎是Sjogren综合征中间歇性肺病的危险因素
Brian Schonewald1,2, Christopher Xie1,2, Andrew Engel1,2
1Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, US.
BMC pulmonary medicine
|November 11, 2025
概括
患有慢性鼻炎的Sjögren综合征患者面临患间歇性肺部疾病的风险更高. 对于患有慢性鼻炎的Sjögren综合征患者,建议对间歇性肺病进行早期查.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 间歇性肺病 (ILD) 是Sjögren综合征 (SS) 的一个重要并发症.
- 在SS中ILD的风险因素仍然不清楚,上空气道和下空气道的参与之间可能存在联系.
- 慢性鼻炎 (CRS) 被假设为SS患者ILD的潜在风险因素.
研究的目的:
- 调查慢性鼻炎 (CRS) 与Sjögren综合征 (SS) 患者间歇性肺病 (ILD) 的发生率之间的关联.
- 确定CRS是否是SS人群中发展ILD的风险因素.
主要方法:
- 对TrinetX研究网络数据库的分析,比较SS患者中发生的ILD,包括有或没有CRS.
- 排除了先前存在ILD或CRS的患者;所有参与者都接受了与SS相关的治疗.
- 在5年和10年内计算ILD的发病率和风险比率 (RR),以混变量进行调整.
主要成果:
- 与没有CRS的患者相比,患有CRS的患者患上ILD的风险明显更高.
- 在5年后,SS患者的ILD发病率为CRS的2.56%和没有的1.66% (调整后RR为1.57).
- 在10年后,SS患者的ILD发病率为3.01%,CRS为1.96%,没有 (调整后RR为1.53).
结论:
- 患有慢性鼻炎的Sjögren综合征患者患间歇性肺部疾病的风险较高.
- 研究结果表明,在被诊断为CRS的SS患者中,可能需要加强对ILD的查.
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