在高心血管风险的男性中,烯摄入量和前列腺癌风险:一项前性队列研究
Ricardo López-Solís1,2, Sara Castro-Barquero2,3,4, Carolina Donat-Vargas1,2,3
1Polyphenol Research Group, Department of Nutrition, Food Science and Gastronomy, XIA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
BMC medicine
|November 11, 2025
概括
较高的烯摄入量与高心血管风险的男性前列腺癌风险降低有关. 这些发现表明,富含白的饮食可能有助于预防前列腺癌,特别是在高危人群中.
科学领域:
- 营养与饮食学 营养与饮食学
- 在瘤学瘤学.
- 心血管健康 心血管健康
背景情况:
- 百合素摄入量正在研究其在预防前列腺癌方面的潜在作用.
- 心血管疾病和前列腺癌之间的共同风险因素可能会影响莱科的作用.
- 这项研究的重点是地中海人口心血管风险高.
研究的目的:
- 检查莱科消费与前列腺癌发病率之间的关联.
- 为了评估高心血管风险的男性队列中的这种关系.
主要方法:
- 来自PREDIMED试验的2970名55-80岁男性的前性队列研究.
- 通过重复的食物频率调查问卷来评估烯摄入量.
- 考克斯比例危险模型用于确定危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在5.8年的时间里,发现了104例前列腺癌病例.
- 最高的百合素摄入四分位数显示前列腺癌风险显著降低 (HR:0.46;95% CI:0.23-0.95).
- 观察到非线性剂量反应,与4.9毫克/天以上的逆相关性 (HR:0.36;95% CI:0.13-0.98).
结论:
- 增加利科摄入量与高风险男性前列腺癌发病率降低有关.
- 富含利可的饮食可能有助于预防前列腺癌.
- 这些发现对心血管风险较高的人群尤为重要.
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