相关实验视频

Updated: Jan 11, 2026

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

巨细胞:关键的编排者和新兴的治疗点在骨关节炎的发病过程中

Jia Hu¹, Jing Wang²

¹Department of Orthopaedics, Xinqiao Hospital, Army Military Medical University, Chongqing, China. hujia642545251@163.com.

Journal of translational medicine

|November 11, 2025

概括

巨细胞是骨关节炎 (OA) 进展的关键参与者,驱动炎症和软骨损伤. 向巨细胞通路为这种广泛的关节疾病提供了有前途的新治疗策略.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
细胞生物学细胞生物学

背景情况:

骨关节炎 (OA) 是一种普遍的关节疾病,影响全球超过5亿人,导致严重的残疾.
巨细胞通过编排突炎和软骨矩阵降解来批判性地调节OA的病变发生.
目前对关节炎病原学的理解仍然不完整,这凸显了对新型治疗点的需求.

研究的目的:

审查骨关节炎的流行病学和病变性.
阐明巨细胞在OA发育中的关键作用,并确定关键的分子标.
讨论针对OA治疗的巨介导途径药物研究的进展.

主要方法:

对流行病学数据和OA病变的文献综述.
对巨细胞两极分化和炎症信号通路 (PI3K/Akt,NF-κB,mTORC1,Wnt/β-catenin,MAPK) 的分析.
对针对OA巨细胞功能的药理干预措施的当前研究的综合分析.

主要成果:

巨细胞是OA中结膜炎和软骨分解的中央调节者.
多种信号通路控制着巨细胞的两极分化和OA关节中的功能.
巨细胞介导途径中的几个分子标显示了OA的治疗潜力.

结论:

了解巨细胞在关节炎发病过程中的作用,对于开发有效的治疗方法至关重要.
向巨细胞特定途径为新型OA药理干预提供了一个有希望的途径.
进一步研究以巨为中心的疗法可能会导致骨关节炎患者的治疗结果得到改善.

关键词:

巨细胞是一个巨细胞.分子目标是分子目标.骨关节炎是一种骨关节炎.两极化的偏化

更多相关视频

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

相关概念视频

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Inflammation

Inflammation

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...