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住院高血糖症增加了急性胰腺炎中尿路感染的风险:基于剂量反应和PSM的分析
Wanyun Tang1, Yan Sun2, Runzhuo Li3
1Department of Orthopedics, Zigong First People's Hospital, Zigong, China.
European journal of medical research
|November 11, 2025
概括
住院时血糖升高会增加急性胰腺炎 (AP) 患者尿路感染 (UTI) 的风险. 控制血糖可能会降低尿路感染率,并改善这一群体的结果.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 急性胰腺炎 (AP) 是一种严重的疾病,可能会导致并发症.
- 尿路感染 (UTI) 是一个常见的医院感染.
- 在AP患者的入院高血糖症和尿路感染之间的关系需要进一步调查.
研究的目的:
- 调查入院高血糖症和尿路感染发病率在AP患者之间的关联.
- 提供证据,证明血糖监测和管理对于预防AP患者尿路感染的重要性.
主要方法:
- 分析了728名AP患者的队列.
- 根据入院血糖水平,患者被分为高血糖和正常血糖组.
- 倾向性得分匹配 (PSM) 和多变量逻辑回归被用于控制混因素和评估尿路感染风险.
主要成果:
- 与正常血糖患者相比,入院高血糖症患者的尿路感染率明显高于正常血糖患者,无论是在PSM前 (28.4%vs7.9%) 还是在PSM后 (18.7%vs8.3%).
- 入院高血糖症被确定为AP患者中尿路感染的独立风险因素 (OR=2.51后PSM).
- 在入院葡萄糖水平和尿路感染风险之间观察到剂量反应关系.
结论:
- 住院高血糖是急性胰腺炎患者发生尿路感染的重要危险因素.
- 存在明显的剂量反应关系,表明较高的葡萄糖水平与增加的尿路感染风险相关.
- 在入院时实施加强血糖监测和管理可能对于减少尿路感染发病率和改善AP患者预后至关重要.
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