微摩擦精子不动化促进受精和卵细胞利用在细胞体内精子注射
Shuai Liu1, Hui Wang2, Meiyi Li2
1Center of Reproductive Medicine, Guangzhou Women and Children's Medical Cente, Guangzhou Medical University, No. 9 Jinsui Road, Tianhe District, Guangzhou, 510623, China. liushuai601@126.com.
Journal of ovarian research
|November 11, 2025
概括
微摩擦精子不动化在细胞内注射精子 (ICSI) 周期中显著改善了受精和胚胎利用率. 这种技术增强了早期胚胎发育,但没有影响活产率.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 不孕症治疗 不孕症治疗
背景情况:
- 精子静止对于细胞内精子注射 (ICSI) 期间的卵细胞激活至关重要.
- 现有的精子固定化技术报告结果不一致,需要进一步研究.
- 这项研究评估了一种新的,温和的机械方法:微摩擦以固定精子.
研究的目的:
- 评估ICSI中微摩擦精子固定技术的有效性.
- 为了比较微摩擦和单触式精子固定方法之间的ICSI结果.
- 研究微摩擦对受精,胚胎发育和临床结果的影响.
主要方法:
- 对2967个ICSI周期 (2018年4月至2023年6月) 进行了一项回顾性队列研究.
- 周期被分为微摩擦和单触式精子固定化组,包括非PGT和PGT-A子组.
- 患者和周期参数被匹配为控制混变量.
主要成果:
- 微摩擦显示出明显更高的受精率 (85.28%与76.06%在非PGT;85.26%与75.45%在PGT-A).
- 微摩擦显著提高了每注射卵细胞的第3天胚胎利用率 (64.13%与非PGT中的50.24%相比; 63.43%与PGT-A中的48.79%).
- 在胚胎囊形成,形积分率,植入或活产率方面没有发现显著差异.
结论:
- 微摩擦精子固定是一种有效的技术,在ICSI中显著增强受精和早期胚胎利用.
- 该技术在改善ICSI后胚胎发育的初始阶段方面表现有前途.
- 微摩擦似乎不会影响最终的临床怀孕或每次移植的活产率.
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