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Updated: Jan 11, 2026

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hs-CRP/HDL-C指数与儿童和青少年超重/肥胖之间的S型关联:基于人口的研究
Zhengjiu Cui1, Zhiyao Zhu1, Jiayi Shao1
1Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
European journal of medical research
|November 11, 2025
概括
超敏感C反应蛋白 (hs-CRP) /高密度脂蛋白胆固醇 (HDL-C) 指数与儿童肥胖有关. 关键指数范围 (0.653-1.593) 显示较低的肥胖率,这表明其用于早期预防.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 生物标志物 生物标志物
背景情况:
- 儿童肥胖是一个全球性的健康问题.
- hs-CRP/HDL-C指数是已知的代谢障碍和炎症的标志物.
- 它在儿童超重和肥胖中的作用需要进一步调查.
研究的目的:
- 分析hs-CRP/HDL-C指数与儿童和青少年超重/肥胖之间的关联.
- 为了确定hs-CRP/HDL-C指数的潜在值效应.
- 为青年早期肥胖预防策略提供基础.
主要方法:
- 利用了NHANES数据 (2015-2020年) 对3853名儿童和青少年 (6-19岁) 的数据.
- 采用后勤回归,受限立方线回归 (RCS) 和零碎回归.
- 研究了非线性模式,并确定了hs-CRP/HDL-C指数的关键值.
主要成果:
- 在日志转换的hs-CRP/HDL-C指数和超重/肥胖之间发现了显著的正相关性 (OR = 5.81).
- 观察到一种非线性,S型的剂量反应关系.
- 确定了hs-CRP/HDL-C指数的两个关键值,分别为0.653和1.593.
结论:
- hs-CRP/HDL-C指数显示了与儿童超重和肥胖的非线性关联.
- 一个特定的指数范围 (0.653-1.593) 与超重/肥胖率的降低有关.
- 建议进行常规hs-CRP/HDL-C测试,以早期识别儿童的风险和预防儿童肥胖.
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