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奎尔赛丁通过与甘氨酸胺核糖核酸转化酶相互作用来缓解乙醇诱导的肝细胞衰老

Chen Huimin¹, Peng Shufen², Cui Zhaoyu³

¹Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan 430030, China.

Food research international (Ottawa, Ont.)

|November 11, 2025

概括

奎尔素通过抑制肝细胞衰老来保护免受酒精性肝病的影响. 它向糖胺基核糖核酸转化酶 (GART),减少纯素代谢和细胞衰老.

科学领域:

肝病学肝病学是一种肝病学.
分子生物学分子生物学
营养科学营养科学

背景情况:

酒精性肝病 (ALD) 构成了严重的健康负担.
奎尔在ALD中表现有希望,但其机制尚不清楚.
了解奎尔丁的分子标对于治疗开发至关重要.

研究的目的:

阐明奎尔塞丁在ALD中的肝脏保护机制.
为了研究氨酸对肝细胞衰老的影响.
通过转录组和代谢组分析识别奎尔丁的分子标.

主要方法:

用利伯-德卡利饮食用乙醇和奎尔丁治疗小鼠.
进行了转录组和代谢组分析,以确定关键的途径和代谢物.
在体外测试 (蛋白质微阵列,细胞热转移测试) 用于验证分子相互作用.

主要成果:

奎尔丁治疗减少了小鼠的肝损伤标志物,甘油三水平和脂质积累.
综合分析揭示了奎尔素对纯素代谢途径的影响,特别是改变了5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR).
奎尔赛丁抑制了乙醇诱导的肝细胞衰老,这种效应被AICAR逆转,并被GART过度表达否定,表明GART是直接的目标.

结论:

奎尔可以缓解乙醇诱导的肝细胞衰老.
该机制涉及氨酸与甘氨胺核酸转化酶 (GART) 相互作用.
这种相互作用调节 purin代谢途径,为ALD提供了新的治疗洞察力.

关键词:

酒精性肝病是一种肝病.肝细胞衰老肝细胞衰老纯氨酸代谢途径纯氨酸代谢途径奎尔丁 (Quercetin) 是一种青素.

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