酒精使用障碍中的甲状腺功能:性别,酒精诱导精神疾病和解毒效应的病例控制和纵向研究
Qing Yu1, Caihong Ye1, Sili Wang1
1Department of Clinical Laboratory, Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen, Guangdong, China.
Journal of addictive diseases
|November 11, 2025
概括
酒精使用障碍 (AUD) 与甲状腺功能障碍有关,与健康人群相比,患者的甲状腺激素水平较低. 监测甲状腺功能对于管理AUD相关症状至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 酒精使用障碍 (AUD) 很普遍,并与各种健康并发症有关.
- 甲状腺功能障碍是AUD患者中已知的并发症.
- 酒精对下丘脑-垂体-甲状腺轴的影响需要进一步阐明.
研究的目的:
- 为了研究与健康对照组相比,AUD患者的甲状腺激素水平.
- 为了检查AUD患者与没有酒精诱导精神疾病 (AIPD) 之间的甲状腺功能差异.
- 在AUD患者中排毒后评估甲状腺功能的变化.
主要方法:
- 对283名AUD患者和300名健康对照进行了回顾性病例对照研究.
- 在入院和排毒后测量甲状腺刺激激素 (TSH),自由甲状腺素 (FT4),自由三甲状腺素 (FT3),甲状腺素 (T4) 和三甲状腺素 (T3).
- 使用配对的t测试和千平方测试进行统计分析.
主要成果:
- 与对照组相比,AUD患者的平均FT4,FT3,T4和T3水平较低,甲状腺异常参数比例较高.
- 与男性相比,患有AUD的女性的TSH升高和FT4,FT3和T3降低的患病率更高.
- 与非AIPD患者相比,AIPD患者的甲状腺激素水平较高;解毒导致甲状腺激素减少和TSH增加,在AIPD病例中更为显著.
结论:
- 酒精使用障碍可以诱导甲状腺功能障碍.
- 患有AUD的患者需要对甲状腺激素水平进行警监测.
- 管理甲状腺功能可能有助于减轻AUD患者的精神和神经症状.
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