2型糖尿病的免疫失调:对结核病,COVID-19和艾滋病毒/艾滋病的影响
Uzair Abbas1, Harendra Kumar2, Niaz Hussain3
1Department of Physiology, Dow University of Health Sciences, Karachi 74200, Pakistan.
糖尿病 (DM) 损害了免疫系统,增加了对结核病,COVID-19和HIV/AIDS等感染的易感性. 有效的血糖控制对于改善患有传染病的糖尿病患者的治疗结果至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 糖尿病 (DM) 是一种慢性疾病,其特征是高血糖,胰岛素抵抗和胰岛素分泌受损.
- 糖尿病显著影响免疫功能,增加对各种感染的易感性.
- 在DM中,慢性炎症和高血糖症与在流行性传染病中增加的脆弱性和较差的结果有关.
研究的目的:
- 审查糖尿病和传染病之间的复杂关系.
- 总结DM对特有感染的易感性,疾病进展和治疗反应的影响.
- 突出免疫调节在DM中所扮演的角色,与传染病结果有关.
主要方法:
- 现有文学作品的叙述性回顾.
- 在PubMed,Scopus和谷歌学者中进行的搜索.
- 专注于流行病学,临床和机理学研究.
主要成果:
- 糖尿病会加剧传染病,包括结核病,COVID-19和艾滋病.
- 在DM中,高血糖和免疫失调与疾病严重程度的增加有关.
- 糖尿病患者血糖控制不良与严重感染和不良结果的风险更高相关.
结论:
- 在DM中免疫调节与传染病结果有显著的反向关系.
- 由于免疫系统下调,DM增加了严重感染的风险.
- 进一步了解DM和免疫控制对于降低风险和改善患者结果至关重要.
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