关节或膝关节置换手术后静脉血栓栓塞的长期风险:基于人口的匹配队列研究
Peng Wu1, Fuxiao Li2, Tengfei Lin1
1Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Research and practice in thrombosis and haemostasis
|November 11, 2025
概括
关节或膝关节置换 (HJR或KJR) 显著增加静脉血栓塞栓症 (VTE) 的风险,该风险在手术后10年内仍然很高. 这种长期风险需要进一步的调查和监测.
科学领域:
- 整形外科手术 整形外科手术
- 血管医学 血管医学
- 流行病学 流行病学
背景情况:
- 关节或膝关节置换 (HJR/KJR) 与短期静脉血栓栓塞 (VTE) 风险有关.
- 有限的数据存在于VTE风险超过一年后HJR/KJR.
研究的目的:
- 为了比较HJR/KJR患者与普通人群的10年VTE风险.
- 为了评估在关节置换手术后的长期VTE风险.
主要方法:
- 使用英国生物库数据进行的前性匹配队列研究.
- 18,984名HJR和16,709名KJR患者与对照进行了匹配.
- 灵活的参数和零件式的考克斯模型,用于10年内随时间变化的危险比率.
主要成果:
- 10年VTE风险为HJR的6.2%,为KJR的7.5%.
- 静脉瘤风险在手术后立即达到峰值,下降,但在10年内仍然升高.
- 在8-10年间,HJR/KJR的危险比率从>24下降到~1.4,但仍然显著.
结论:
- 在HJR或KJR之后的10年内,VTE风险显著增加.
- 需要进行进一步的研究,扩展后续跟踪和详细的共变量.
- 关节置换后的长期VTE风险表征需要进一步研究.
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