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分析儿科呼吸道病毒流行病学及其与成都大气参数的关联

Hao Dong¹, Luoman Yan¹, Haiyan Zhang²

¹Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Translational pediatrics

|November 11, 2025

概括

在COVID-19流行后,这项研究分析了中国成都的儿科呼吸道病毒模式. 人类犀牛病毒 (HRV) 是最常见的,在病毒活动和当地大气条件 (如温度和空气污染物) 之间发现了显著的关联.

科学领域:

儿童传染病儿童传染病
环境流行病学环境流行病学
病毒学病毒学

背景情况:

在COVID-19之后,非药物干预措施 (NPIs) 的放松影响了全球呼吸道病毒流行病学.
这项研究侧重于中国成都的住院儿童,以了解常见呼吸道病毒的局部模式.
研究了这些病毒与大气参数之间的关联.

研究的目的:

描述常见的呼吸道病毒在成都住院儿童的流行病学模式.
调查儿科呼吸道病毒活动与当地大气条件之间的关系.

主要方法:

从2023年1月到2024年12月,对患有急性呼吸道感染 (ARI) 的儿童的临床数据进行了回顾性分析.
多重实时PCR被用于检测人类犀利病毒 (HRV),人类腺病毒 (HADV),人类呼吸道同胞病毒 (HRSV),甲型流感 (InfA) 和乙型流感 (InfB).
每月平均大气数据 (温度,湿度,AQI,PM2.5,PM10,NO2,SO2,CO,O3) 被收集并统计分析与病毒检测率的相关性.

主要成果:

在322,238名测试儿童中,9.47%的儿童至少有一种病毒呈阳性,HRV是最常见的 (3.84%).
感染率在男性和学龄前儿童中较高,观察到明显的季节性变化.
人类呼吸道同胞性病毒 (HRSV) 与最严重的结果有关,并且在温度,空气污染物 (PM2.5,PM10,NO2) 和特定病毒活动之间发现了显著的相关性.

结论:

该研究提供了关于成都儿科呼吸道病毒局部流行病学的见解.
大气因素和病毒检测之间的显著关联突出了潜在的环境影响.
调查结果可以为区域预防策略和个性化儿童健康保护措施提供信息.

关键词:

孩子孩子孩子孩子空气污染空气污染流行病学流行病学多重实时光聚合酶连锁反应.呼吸道病毒的病毒.

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