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临床特征和成像异常的危险因素在儿科B组链球菌脑膜炎:一个多中心研究

Xinxin Liu¹, Hongmei Xu², Gang Liu³

¹Department of Infectious Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Translational pediatrics

|November 11, 2025

概括

婴儿的B组链球菌 (GBS) 脑膜炎往往导致内成像异常. 关键的危险因素包括同时呈阳性血液和脑脊液培养物,以及初始低的脑脊液葡萄糖水平.

科学领域:

儿童传染病儿童传染病
新生儿神经病学新生儿神经病学
神经辐射学神经辐射学

背景情况:

乙组链球菌 (GBS) 脑膜炎是婴儿发病的重要原因之一.
脑内成像异常在儿科GBS脑膜炎中很常见,与疾病严重程度相关.
了解这些异常的风险因素对于早期干预至关重要.

研究的目的:

确定诊断为GBS脑膜炎的儿童内成像异常的独立风险因素.
为早期识别患有GBS脑膜炎的高风险儿科患者提供基础.

主要方法:

在12家中国医院对327例儿科GBS脑膜炎病例进行了回顾性分析 (2019年1月 - 2020年12月).
收集的数据包括临床特征,脑脊液 (CSF) 分析和成像发现.
使用多变量逻辑回归来确定独立的风险因素.

主要成果:

65.2%的患者出现了成像异常,最常见的是体内液.
患有异常的患者的结果较差,包括神经系统后果的更高率.
确定的独立风险因素是同时呈阳性CSF和血液培养物 (OR=1.945) 和初始CSF葡萄糖<1.57 mmol/L (OR=0.7).

结论:

儿童GBS脑膜炎,特别是在3个月以下的婴儿中,经常出现成像异常.
同时呈阳性CSF和血液培养和初始低CSF葡萄糖是显著的预测因素.
早期识别这些风险因素可以指导管理并改善结果.

关键词:

乙组链球菌 (GBS) 是一种图像异常的成像异常脑膜炎是一种脑膜炎.儿科儿科儿科儿科

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