用吸入性胰岛素替换或补充自动化胰岛素输送:90天随机对照试验
Kevin B Kaiserman1, Johanna Ulloa1, Jennifer Pleitez1
1MannKind Corporation, Westlake Village, CA, USA.
Journal of diabetes science and technology
|November 11, 2025
概括
技术界胰岛素 (TI) 是一种吸入的超快速作用胰岛素,被评估为1型糖尿病中自动化胰岛素输送系统 (AID) 的补充或替代品. 该研究发现,当添加到AID或与基底胰岛素一起使用时,TI对饮食时血糖控制是安全有效的.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 科技界胰岛素 (TI) 是一种用于糖尿病管理的超快速起作用的吸入胰岛素.
- 这项研究探讨了使用更高的修改剂量的TI来补充或取代自动化胰岛素输送 (AID) 系统.
研究的目的:
- 评估Technosphere胰岛素 (TI) 在1型糖尿病成年人中与自动胰岛素输送系统 (AID) 一起使用时的安全性和有效性.
- 评估TI在血糖控制,肺功能和不良事件中的作用.
主要方法:
- 使用AID的1型糖尿病成年人被随机分为三组:TI + AID,TI + 胰岛素降解剂,或控制 (仅使用AID).
- 治疗持续时间为90天,评估包括HbA1c,FEV1,低血糖和不良事件.
主要成果:
- 所有组都显示出可比的HbA1c下降;对照组有统计学上显著的下降.
- 两组之间没有观察到FEV1或低血糖率 (包括严重事件) 的显著差异.
- 没有报告严重的不良事件;两名参与者经历了与TI (肺功能下降,喘息) 相关的特别感兴趣的副作用.
结论:
- 这项概念验证研究表明,Technosphere胰岛素 (TI) 是安全有效的.
- TI可用于补充饮食时间控制的AID系统,或使用基底胰岛素以更高的修改剂量进行整体血糖管理.
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