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Updated: Jan 11, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
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PCBP2 调节p16INK4a-依赖细胞衰老的反应对铁

Shaoyang Yan1,2, Lili Lu1, Yuwei Wu1,3

  • 1Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Aging cell
|November 11, 2025
PubMed
概括

铁通过PCBP2蛋白和rs1333046遗传变异促进细胞衰老,从而影响动脉样硬化. 这个过程涉及调节p16INK4a和CD40的表达,突出铁.

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