在小儿麻醉中呼吸道操纵期间局部利多卡因:系统性审查和元分析
Elizabet Taylor Pimenta Weba1, Gabriel Soares de Sousa2,3,4, Alexandros Páris de Mesquita Ipácio1
1State University of Maranhão Tocantine Region, Imperatriz, Brazil.
Paediatric anaesthesia
|November 11, 2025
概括
在接受呼吸道管理的儿科患者中,局部利多卡因显著减少喉,脱和喉疼痛. 对于其他呼吸系统不良事件,特别是高风险儿童,需要进一步研究.
科学领域:
- 麻醉学 麻醉学
- 儿科重症监护 儿科重症监护
- 呼吸系统医学 呼吸系统医学
背景情况:
- 局部利多卡因在儿科麻醉中经常用于呼吸道管理,以减轻呼吸道和循环反射.
- 在预防儿童呼吸系统不良事件方面,局部利多卡因的确切疗效仍然不完全理解.
- 这一元分析解决了对局部利多卡因对儿科呼吸道管理结果的影响进行全面评估的需要.
研究的目的:
- 进行元分析,评估局部利多卡因在儿童患者呼吸道管理期间减少呼吸系统不良事件的有效性.
- 综合随机对照试验的证据,以澄清局部利多卡因在儿科麻醉中的作用.
主要方法:
- 在PubMed,Embase和Cochrane数据库中的系统文献搜索.
- 包括14项随机对照试验,涉及1937名儿科患者.
- 使用随机效应模型进行统计分析,以计算几率比率和平均差异,以95%的置信区间.
主要成果:
- 局部利多卡因显著降低了喉发作 (OR 0.50),脱 (OR 0.49) 和喉疼痛 (OR 0.31) 的发生率.
- 在支气管,咳,严重咳,声,吐或心率方面没有发现显著差异.
- 该分析包括1937名儿科患者,其中917人接受了用于呼吸道手术的局部利多卡因.
结论:
- 局部利多卡因在减少儿科患者的特定气道反射,如喉,脱和喉痛等方面具有潜在的益处.
- 该研究强调需要对局部利多卡因对其他外科手术期间呼吸系统不良事件的影响进行更多研究,特别是在脆弱的儿科患者群体中.
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