在垃圾填埋场的泄物中,金属耐药性-毒性共同选择的驱动因素
Chenglong Zhang1, Ning Chang1,2, Guangxuan Yin3
1School of Resources and Environmental Engineering, Shanghai Polytechnic University, Shanghai Collaborative Innovation Center for WEEE Recycling, Shanghai 201209, China.
Journal of applied microbiology
|November 11, 2025
概括
垃圾填埋场液中的重金属驱动金属耐药性基因 (MRG) 和毒性因子基因 (VFG) 的共同选择,增强病原体的感染力并构成生态风险. 这项研究揭示了由环境因素塑造的关键病原体-基因相互作用.
科学领域:
- 环境微生物学环境微生物学
- 转基因组学是指转基因组学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 耐金属基因 (MRG) 和毒性因子基因 (VFG) 通常是独立研究的.
- 在垃圾填埋场液中MRG和VFG的共同选择动态尚不清楚.
- 垃圾填埋场的泄物代表了复杂的环境,具有基因交换的潜力.
研究的目的:
- 在多个地区的垃圾填埋场中调查MRG和VFG在垃圾填埋场中的共同选择.
- 确定环境因素,特别是重金属对这些相互作用的影响.
- 评估相关的生态和健康风险.
主要方法:
- 来自中国13个地点的垃圾填埋场液样本的多区域元基因组测序.
- 同时发生网络分析以确定病原体-基因关系和功能模块.
- 冗余分析以将重金属度与基因组合相关联.
主要成果:
- 在病原体,MRG和VFG分布中观察到显著的区域差异.
- 确定了一个"金属耐药性-毒性"协同模块,其中以大肠杆菌,沙门氏菌和Acinetobacter baumannii作为中心节点.
- 发现特定的重金属 (Cu,Zn,Cr,As) 是形成"病原体-MRG-VFG"组件的关键驱动因素.
结论:
- MRG 提供了生存优势,并与 VFG 协同作用,增强了垃圾填埋环境中的病原体感染力.
- 重金属在MRG和VFG的共同选择中发挥着至关重要的作用.
- 调查结果为有针对性的监测策略提供信息,以减轻与垃圾填埋污水相关的环境和公共卫生风险.
相关概念视频
01:28Microbial Nutrition
1.0K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.0K
01:30Development of Antibiotic Resistance
1.2K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.2K
01:16Transduction
1.2K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.2K
01:31Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
01:26Transformation
666
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
666
00:57Antibiotic Selection
59.3K
Overview
59.3K