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暴露于艾滋病毒的儿童和青少年的工作记忆和处理速度较低

Maryjane I Okhagbuzo¹, Irene Njuguna^1,2, Maureen King'e³

¹Departments of Global Health.

AIDS (London, England)

|November 11, 2025

概括

与未暴露的同龄人 (CHU) 相比,暴露于艾滋病毒的儿童 (CHEU) 的工作记忆和处理速度较低. 干预措施应侧重于孕产妇的ART和粮食安全,以改善CHEU的认知结果.

科学领域:

神经科学是一个神经科学.
儿科健康儿科健康
公共卫生公共卫生

背景情况:

暴露于艾滋病毒 (CHEU) 的儿童可能面临影响发展的认知挑战.
了解艾滋病毒暴露和未暴露儿童之间的认知差异对于有针对性的支持至关重要.
社会经济和母亲健康因素可以影响儿童的认知结果.

研究的目的:

为了比较暴露于艾滋病毒 (CHEU) 和未暴露 (CHU) 的7-18岁儿童之间的认知功能.
确定与CHEU认知功能低下相关的因素.
为改善CHEU的认知健康提供潜在干预措施的信息.

主要方法:

采用了横截面调查设计.
用NIH工具箱非洲语言认知电池评估认知功能,测量工作记忆,注意力,处理速度等.
多变量线性回归被用来确定认知功能的相关性,调整混因素.

主要成果:

与未暴露儿童 (CHU) 相比,暴露于艾滋病毒 (CHEU) 的儿童在工作记忆和处理速度方面的得分明显较低.
在CHEU中,孕期母体组合抗逆转录病毒疗法 (ART) 与更好的工作记忆有关.
粮食不安全与CHEU的处理速度较差有关,而母亲的教育和男性性别与两组的更好的认知结果有关.

结论:

CHEU会出现特定的认知缺陷,特别是在工作记忆和处理速度方面.
孕产妇的ART和解决粮食不安全问题是加强CHEU认知功能的干预措施的潜在目标.
对CHEU认知差异背后的机制进行进一步研究是有必要的,以指导有效的支持策略.

关键词:

青少年是一个青少年.孩子孩子孩子孩子孩子孩子认知能力认知能力认知能力艾滋病病毒艾滋病病毒艾滋病病毒记忆记忆记忆记忆记忆处理速度处理速度

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