对癌症复发恐惧的电子健康干预:一项随机临床试验
Johanne Dam Lyhne1,2, Allan Ben Smith3,4, Signe Timm1,2
1Department of Clinical Oncology, University Hospital of Southern Denmark, Vejle, Denmark.
JAMA network open
|November 11, 2025
概括
在使用治疗师指导的电子健康计划TG-iConquerFear的结直肠癌幸存者中,癌症复发的恐惧 (FCR) 显著下降. 这种在线干预为管理FCR后处理提供了一个有希望的,可访问的选择.
科学领域:
- 在瘤学瘤学.
- 心理学 心理学 心理学
- 数字健康数字健康
背景情况:
- 对癌症复发的恐惧 (FCR) 是癌症幸存者的重要关注点,影响生活质量.
- 需要有效的干预措施来解决FCR问题,平衡可访问性和临床疗效.
- 电子健康干预提供了一个可扩展的解决方案,用于管理癌症幸存者的心理痛苦.
研究的目的:
- 评估为期10周的治疗师指导 (TG) 电子健康干预TG-iConquerFear在减少结直肠癌 (CRC) 幸存者中的FCR方面的有效性.
- 评估可访问的在线课程对癌症幸存者的心理健康的影响.
- 确定电子健康方法是否可以提供临床上有意义的FCR降低.
主要方法:
- 一项随机临床试验,涉及无癌症的成年CRC幸存者,具有临床显著的FCR (FCRI-SF得分≥22).
- 参与者被随机 (1:1) 分给TG-iConquerFear干预或增强的对照组.
- 该TG-iConquerFear干预包括6个模块,在10周内进行异步治疗师指导.
主要成果:
- 与对照组 (平均变化 -2.6分) 相比,TG-iConquerFear组在干预后3个月的FCR总得分显著下降 (平均变化-21.7分).
- 在TG-iConquerFear组的参与者中,显著更高的比例在3个月内实现了低于临床截止值的FCR得分 (81%对43%).
- 干预表明了统计学上显著的群体间差异 (19.1分,P < .001) 与中等效应大小 (科恩d = 0.62).
结论:
- 治疗师指导的电子健康干预TG-iConquerFear显著减少了CRC幸存者对癌症复发的恐惧.
- 这项研究表明,电子健康干预可以有效地扩大FRC的治疗选择,超越传统的面对面治疗方法.
- TG-iConquerFear是一个可行的和有效的数字工具,用于管理癌症幸存者的心理痛苦.
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