绿色合成的银纳米粒子从Cotoneaster horizontalis,在玻璃和在的抗菌性质
Yunus Basar1, Aybek Yigit2, G Fru Chi3,4
1Research Laboratories Application and Research Center (ALUM), Igdir University, Igdir, Turkiye.
Chemistry & biodiversity
|November 11, 2025
概括
从Cotoneaster horizontalis甲醇提取物合成的银纳米粒子 (AgNPs) 与单独的植物提取物相比,显示出增强的抗菌特性. 这些AgNP为对抗耐药细菌提供了一个有希望的天然替代品.
科学领域:
- 自然产品化学 自然产品化学
- 纳米技术纳米技术
- 微生物学 微生物学
背景情况:
- 抗菌素耐药性是全球卫生危机,需要新的治疗策略.
- 自然产品是发现新抗菌剂的重要来源.
- 科托纳斯特 (Cotoneaster horizontalis) 是一种具有潜在药用功能的植物.
研究的目的:
- 为了比较Cotoneaster horizontalis甲醇提取物及其衍生的银纳米粒子 (AgNPs) 的抗菌疗效.
- 识别生物活性化合物和表征合成的AgNP.
- 为了研究抗菌作用机制.
主要方法:
- 使用GC-MS/MS和LC-ESI-MS/MS进行代谢物分析.
- 通过FT-IR,XRD,FE-SEM和FE-SEM-EDAX进行AgNP的表征.
- 分子对接与金黄色葡萄球菌分类酶-A和PASS分析.
主要成果:
- 在提取物中确定了包括基酸,异基和鲁丁在内的关键代谢物.
- 合成的AgNP在结构上具有特征.
- AgNPs表现出剂量依赖的抗菌活性,在体外表现优于甲醇提取物.
结论:
- 从C. horizontalis甲醇提取物合成的AgNP与单独提取物相比具有更高的抗菌活性.
- 抗菌作用很可能通过抑制类酶-A和作为膜完整性对手的作用来调解.
- 这项研究强调了植物衍生AgNP作为一种新型抗微生物策略的潜力.
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