补体调节受损导致肺移植后慢性肺异位功能障碍

相关实验视频

Updated: Jan 11, 2026

11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.6K

Hrishikesh S Kulkarni^1,2, Laneshia K Tague¹, Daniel R Calabrese^3,4

¹Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

The Journal of clinical investigation

|November 11, 2025

概括

对补充激活的遗传倾向,特别是C3 R102G多态性,与肺移植 (LTx) 后更糟糕的慢性肺异位功能障碍 (CLAD) 无生存有关,这是由于抗体反应的增加.

科学领域:

免疫学免疫学免疫学
移植生物学移植生物学
遗传学遗传学是一个

背景情况:

慢性肺异位移植功能障碍 (CLAD) 是肺移植 (LTx) 后的主要死亡原因.
补体系统在免疫反应中起着至关重要的作用,并在LTx.后的早期被激活.
了解CLAD病理生物学对于改善LTx结果至关重要.

研究的目的:

研究LTx受体中对增强补充激活的遗传倾向与CLAD无生存率之间的关联.
探索C3 R102G多态性在CLAD发育和免疫中的作用.
阐明在LTx.中将补体失调与幽默性免疫反应联系起来的机制.

主要方法:

在两个独立的LTx受体队列中分析一个功能C3多态 (C3 R102G).
关联研究将C3 R102G基因型与无CLAD存活率和供体特异性抗体 (DSAs) 相关联.
利用小鼠的 орто托普 LTx 模型来研究受损补体调节对 CLAD 病理学的影响.

主要成果:

在超过三分之一的LTx接受者中存在的C3 R102G多态性与明显更差的CLAD无生存率有关.
这种关联在患有DSA的接受者中尤为明显.
在小鼠模型中,补体调节受损导致B细胞依赖的CLAD和增加DSA水平.

结论:

通过C3 R102G,对补充激活的遗传倾向有助于LTx后较差的CLAD无生存.
增强的补体激活促进有害的幽默免疫反应,其特征是增加DSAs.
向补剂失调可能是改善LTx结果的治疗策略.

关键词:

补充补充补充补充免疫学免疫学免疫学器官移植器官移植器官移植肺部病理学肺部病理学

相关概念视频

01:40

Cell-mediated Immune Responses

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.2K

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

4.2K

01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.5K

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

3.5K

01:29

Pulmonary Tuberculosis I

816

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

816

01:24

Tissue Transplantation

883

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

883

01:22

Chronic Obstructive Pulmonary Disease

2.2K

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...