PersADE:个性化药物不良事件及其潜在分子机制的数据库
Zhuohang Yu1, Yimeng Wang2, Yintao Zhang2
1Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
新的数据库PersADE现在提供了个性化的不良药物事件 (ADE) 数据和分子机制. 该资源有助于精准医学研究,并通过详细介绍药物-ADE关联和相互作用来提高药物安全性.
科学领域:
- 药物基因组学 药物基因组学
- 药品安全 药品安全
- 计算生物学 计算生物学
背景情况:
- 药物不良事件 (ADEs) 对全球健康造成重大负担,影响发病率,死亡率和医疗保健成本.
- 精准医学需要了解个性化的ADEs及其分子基础,以实现药物的重新用途和安全性.
- 现有的研究缺乏一个中央数据库来提供个性化的ADE信息.
研究的目的:
- 构建PersADE,一个针对个性化药物不良事件及其分子机制的全面数据库.
- 为准确医学领域的研究人员和临床医生提供宝贵的资源.
- 促进对个性化的ADE和机械探索的研究.
主要方法:
- 整合了4,061,772个个性化药物-ADE协会.
- 包括31,756个蛋白质-ADE协会和108,677个药物-蛋白质相互作用.
- 强调了非目标效应,并包括了ADE分层的人口,疾病和药物参数.
主要成果:
- 开发了PersADE,这是一个新的数据库,整合了广泛的个性化药物ADE数据.
- 通过系统地整合药物,蛋白质和ADE相互作用,实现了详细的机制性见解.
- 根据患者和药物特征提供了分层的药物-ADE关联.
结论:
- PersADE为个性化的ADE研究提供了一个独特的,基于证据的资源.
- 该数据库支持精准医学和药物安全性评估方面的进展.
- 预计自由访问的数据将对临床和研究应用产生重大影响.
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