Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Improving Translational Accuracy02:07

Improving Translational Accuracy

3.5K
3.5K
Improving Translational Accuracy02:07

Improving Translational Accuracy

14.0K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.0K
Translation01:31

Translation

155.0K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
155.0K
Translation01:31

Translation

17.5K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
17.5K
Termination of Translation01:44

Termination of Translation

27.4K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.4K
Termination of Translation01:44

Termination of Translation

6.5K
6.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Berberine as an Antimicrobial Agent and Gut Microbiota Modulator: Mechanisms and Therapeutic Potential.

Current medicinal chemistry·2026
Same author

Deep learning in tumour genomics: from multi-omics integration to precision oncology.

Open biology·2026
Same author

Comparison of the efficacy of different orthotopic neobladder reconstruction techniques following radical cystectomy for bladder cancer: a network meta-analysis.

Frontiers in oncology·2026
Same author

StNF-YC9 and StWRKY75 synergistically regulate StPAP10b-mediated root phosphatase activity to drive soil organic phosphorus mobilization in potato.

The Plant cell·2026
Same author

A blood-urine regulatory axis: Tumor-derived factors reprogram urine-derived stem cells via CXCL2/CXCR2/ERK signaling to drive bladder cancer stemness.

Cancer letters·2026
Same author

Efficient inverse design of long-wave infrared metalenses: frequency-domain physics-model-informed neural networks.

Optics express·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
查看所有相关文章

相关实验视频

Updated: Jan 11, 2026

RBDT: A Computerized Task System based in Transposition for the Continuous Analysis of Relational Behavior Dynamics in Humans
11:09

RBDT: A Computerized Task System based in Transposition for the Continuous Analysis of Relational Behavior Dynamics in Humans

Published on: July 17, 2021

3.4K

TEDD:一个全面的翻译效率动态数据库.

Wenyan Lei1,2,3, Cuidan Li1,2, Hengyu Zhou1,2,4

  • 1China National Center for Bioinformation, Beijing 100101, China.

Nucleic acids research
|November 11, 2025
PubMed
概括
此摘要是机器生成的。

我们开发了TEDD,它是人类翻译效率 (TE),翻译比率 (TR) 和延长速度指数 (EVI) 的数据库. 它整合了多omics数据,以探索跨越各种生物背景的UTR特征的翻译调节.

更多相关视频

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

69.7K
Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
10:59

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling

Published on: May 19, 2014

18.8K

相关实验视频

Last Updated: Jan 11, 2026

RBDT: A Computerized Task System based in Transposition for the Continuous Analysis of Relational Behavior Dynamics in Humans
11:09

RBDT: A Computerized Task System based in Transposition for the Continuous Analysis of Relational Behavior Dynamics in Humans

Published on: July 17, 2021

3.4K
Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

69.7K
Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
10:59

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling

Published on: May 19, 2014

18.8K

科学领域:

  • 分子生物学分子生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 翻译对于基因表达和生物学表型至关重要.
  • 在不同环境中量化翻译效率 (TE),启动 (TR) 和延伸 (EVI) 是有限的.
  • UTR特征显著调节发育和疾病中的翻译.

研究的目的:

  • 为人类TE,TR和EVI创建一个全面的数据库 (TEDD).
  • 专注于5'/3' UTR特征在翻译调节中的作用.
  • 为探索特定上下文的翻译控制提供资源.

主要方法:

  • 整合了来自143个人类项目的1518个RNA-seq,Ribo-seq和RNC-seq样本.
  • 在基因和转录水平计算了TE,TR和EVI指标.
  • 有注释的监管5'/3' UTR特征用于详细分析.

主要成果:

  • TEDD提供了24种组织/细胞类型,74种细胞系和52种疾病的综合数据.
  • 这些指标与详细的UTR注释相配对,以便进行细致的调查.
  • 该数据库能够在基因,转录和基因组之间进行多维比较.

结论:

  • TEDD是研究人类翻译控制的宝贵资源.
  • 它支持基础和翻译性研究,包括mRNA疫苗设计和基因治疗.
  • 数据库有助于探索翻译调节机制及其应用.