相关实验视频

Updated: Jan 11, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
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Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

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RNA结合蛋白RBM39架构了一个m6A依赖的RNA衰变复合物,它破坏了Tat转录的稳定,并限制了HIV-1的重新激活

Xiaohui Deng1,2, Siyi Xie1, Mo Zhou3

  • 1Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, Guangdong, China.

PLoS biology
|November 11, 2025
PubMed
概括

研究人员发现RBM39组织了一个使HIV-1沉默的复合物,保持病毒延迟. 降解RBM39可重新激活潜伏的HIV-1,为治愈艾滋病提供了一种新的治疗策略.

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