相关实验视频

Updated: Jan 11, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

骨髓爆发和修改EASIX引导的凝血病风险分层以及复发/耐药B-ALL中CAR-T治疗后的结果

Yingying Li¹, Jiachen Liu¹, Lili Luo¹

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, 430022, China; Hubei Clinical and Research Center of Thrombosis and Haemostasis, Wuhan, 430022, China.

Thrombosis research

|November 11, 2025

概括

一个新的模型预测了B-ALL患者的CAR T细胞相关凝血病 (CARAC) 风险. 高风险的CARAC,特别是DIC,表明生存结果明显较差.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

化学抗原受体 (CAR) T细胞疗法是B细胞急性淋巴细胞白血病 (B-ALL) 复发/耐药的突破.
卡尔T细胞相关凝血病 (CARAC) 是一种严重的并发症,增加了出血和传播性血管内凝血 (DIC) 的风险.

研究的目的:

开发CARAC风险分层的预测模型.
评估CARAC对患者结果的影响,包括整体存活率 (OS) 和无进展存活率 (PFS).

主要方法:

一项针对接受CD19 CAR-T治疗的r/r B-ALL患者的多中心回顾性研究.
机器学习和物流回归被用来识别关键预测因素和构建预测模型.
使用ROC曲线,校准和临床决策曲线验证模型性能;生存分析评估结果.

主要成果:

骨髓爆发和修改的内皮激活和压力指数 (mEASIX) 是独立的CARAC预测指标.
开发了一个风险分层:低风险 (mEASIX<4.0),高风险的CARAC-nonDIC (mEASIX≥4.0,10-44%的爆发),以及高风险的CARAC-DIC (mEASIX≥4.0,≥44%的爆发).
与非CARAC患者相比,CARAC患者的OS和PFS明显恶化;随着CARAC风险的增加,结果逐渐恶化.

结论:

已经建立了一个有效的CARAC风险预测和分层模型.
高风险的CARAC,特别是CARAC-DIC,与明显较差的患者结局有关.

关键词:

B-ALL,所有的人.化学抗原受体-T细胞治疗凝血病是一种凝血病.预测预后预测预测风险分层是指风险的分层.

更多相关视频

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

相关概念视频

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...