血代谢分析确定高水平的海普酸盐是青少年无病性关节炎中甲状腺素不响应的潜在生物标志物
Amar Kumar1, Mara L Becker2, Ryan S Funk3
1Department of Physiology and Biophysics, University of Illinois, Chicago, IL 60612, USA.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|November 11, 2025
概括
血代谢分析确定了hippurate作为预测青少年异常性关节炎 (JIA) 中甲状腺素不响应的关键生物标志物. 这一发现可能有助于个性化JIA患者的治疗策略.
科学领域:
- * 生物化学和代谢学
- * 儿童类风湿病学
- * 药物基因组学 药物基因组学
背景情况:
- * 甲甲酸 (MTX) 是青少年异常性关节炎 (JIA) 的主要疾病修饰性抗风湿药物 (DMARD).
- *MTX反应往往是延迟和可变的,需要生物DMARDs.
- * 预测性生物标志物对于早期,有效的JIA治疗选择是必要的.
研究的目的:
- * 为了确定与JIA中MTX无反应相关的血代谢生物标志物.
- * 利用代谢概况来指导JIA治疗中的药物选择.
主要方法:
- * 60名JIA患者开始MTX治疗的前性观察性研究.
- *多平台UHPLC-MS/MS用于血代谢物 (902种代谢物) 的分析.
- *统计分析包括单变量分析,丰富分析 (ChemRich),代谢网络映射 (MetaMapp) 和ROC曲线分析.
主要成果:
- * 在902个预处理血代谢物中,63个在MTX响应者和不响应者之间有显著差异.
- * 六个代谢物,包括英多尔和丁,是显著的.
- *血中皮酸盐水平升高 (AUC=0.781) 是MTX无反应的最有区别的代谢物,与6个月无反应独立相关.
结论:
- * 血代谢的差异与JIA中的MTX反应有关.
- * 肠道微生物衍生的代谢物,如hippurate和indoles,都与此有关.
- * 结果突出了肠道微生物组在JIA的MTX治疗反应中的潜在作用.
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