新的Ce/Cu修饰黑色陶破坏了线粒体功能障碍和三酸循环,在骨髓瘤细胞中诱导了cuproptosis
Rongxiang Zhang1, Xuelei Yin2, Zenghui Xu2
1School of Materials Science and Engineering, Shandong University, Shandong, China.
Biomaterials advances
|November 11, 2025
概括
经过Ce/Cu修饰的黑色陶通过诱导cuproptosis和线粒体功能障碍,表现出强大的抗骨髓瘤活性. 这些发现支持了这些先进的陶材料在癌症治疗中的临床潜力.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 瘤学研究研究
背景情况:
- 骨髓瘤仍然是治疗骨癌的一个重大挑战.
- 开发具有向抗瘤活性的新型治疗材料至关重要.
- 陶材料由于其生物相容性和可调性特性,因此具有生物医学应用的潜力.
研究的目的:
- 开发和描述/铜 (Ce/Cu) 改性黑色陶.
- 为了研究这些改性陶的抗骨肉瘤机制.
- 探索cuproptosis和PI3K/AKT通路在抗瘤作用中的作用.
主要方法:
- 使用EDS,机械测试和抗菌检测,制备和表征Ce/Cu合黑色陶.
- 在陶基板上评估骨髓瘤细胞 (MNNG/HOS,MG63) 的粘附,形态和活力.
- 在体外分析cuproptosis,线粒体功能障碍,TCA循环中断和PI3K/AKT通路的参与.
主要成果:
- 经过Ce/Cu修饰的黑色陶对抗骨髓瘤细胞表现出优异的抗瘤特性.
- 陶产生的线粒体功能障碍和破坏TCA循环代谢,导致cuproptosis.
- 鉴定PI3K/AKT通路是用Ce/Cu陶处理的骨髓瘤细胞中亡的一个关键媒介.
结论:
- 经过Ce/Cu修饰的黑色陶通过cuproptosis诱导显示出显著的抗骨髓瘤作用.
- 这些发现为这些先进的陶材料的抗瘤活性提供了机制的理解.
- 这项研究支持Ce/Cu修饰黑色陶在骨髓瘤治疗中的临床潜力.
更多相关视频
06:00Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
Published on: September 13, 2017
7.6K
11:15A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.6K
相关概念视频
Inhibition of Cdk Activity
5.5K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.5K
Electron Transport Chain: Complex I and II
18.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
18.4K
Drugs that Stabilize Microtubules
2.6K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.6K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
